Aiming at discovery of new drugs and elucidation of viral evolution, we investigate the following subjects expanding from chemistry to biology.

1. 1.Development of an AIDS eradication strategy using phosphoinositide derivatives.
2. 2.Development of anti-fibrosis and anti-cancer metastasis drugs.
3. 3.Development of brain-targeting drugs.
4. 4.Development of compounds affecting zinc enzymes and signaling proteins.
5. 5.Development of anti-virus agents including anti-HIV compounds.
6. 6.Function analysis of HIV Vpr/Vpx proteins to elucidate viral evolution paradigm.