We have undertaken research on the development of the world’s first therapeutic agents for male infertility.
Spermatozoa can transmit genetic information to the next generation. The cell adhesion molecules between spermatogenic and Sertoli cells as well as paracrine and intratesticular local factors are required for the regulation of spermatogenesis.
We research the roles of many cell adhesion molecules expressed in seminiferous epithelium. We are also working to elucidate new functions of the blood-testis barrier. We are challenging the established theory that the blood-testis barrier exists to protect spermatocytes, spermatids, and spermatozoa from the immune system.
The causes of male infertility are the disorders of spermatogenesis, in which the molecular mechanism remains to be identified. We contribute to the elucidation of the causes of male infertility and establish its treatments.