|The research we intend to conduct has a translational potential in the field of pediatric surgery and organ transplantation. Biliary atresia is one of our targets to disclose the mechanism and progression, in cooperation with basic research groups. In organ transplantation research field, to investigate the mechanism of ischemia reperfusion injury of liver and small intestine, we successfully use two-photon laser scanning microscopy for intravital imaging of real-time neutrophil recruitment. Also, the studies cancer immunotherapy by utilizing macrophages from human iPS cells and elucidating dynamics of regulatory T lymphocytes which modulate immunological response are now ongoing. These are originated from the clinical problems to be overcome.