Metabolic Medicine

In the Department of Metabolic Medicine, we are conducting clinical research aimed at advanced medical care by advancing the molecular biological elucidation of pathological conditions in diabetes, metabolic diseases, and endocrine diseases.

In the field of obesity and diabetes, we are focusing on the studies of the

1. Elucidation of the pathogenesis of type 2 diabetes and development of new treatments
2. Application of Brown Adipocyte-Activating Factors in the Regulation of Energy Metabolism
3. Identification of Factors Involved in the Maintenance of Insulin Signaling Homeostasis and Elucidation of the Underlying Mechanisms
4. Basic and Mechanistic Research on Diabetes and Sarcopenia
5. Research on the significance of insulin action in the regulation of pancreatic acinar cells
6. Elucidation of the onset mechanism of type 2 diabetes due to aging in Japanese

In the field of endocrinology, we are focusing on the studies of the

1. Role of inflammatory cytokines in primary aldosteronism
2. Pathophysiology of glucose intolerance in acromegaly.

In the field of lipid metabolism and atherosclerosis, we are focusing on the studies of the

1. Research on preventing the progression of arteriosclerosis by regulating macrophage proliferation

Reference：

1. Sakaguchi M, Okagawa S, Okubo Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, Araki E. Phosphatase Protector Alpha4 (α4) is involved in Adipocyte Maintenance and Mitochondrial Homeostasis through Regulation of Insulin Signaling.
   Nature Commun. 13(1):6092, 2022.
2. Okagawa S, Sakaguchi M, Okubo Y, Takekuma Y, Igata M, Kondo T, Takeda N, Araki K, Brandao BB, Qian WJ, Tseng YH, Kulkarni RN, Kubota N, Kahn CR, Araki E. Hepatic SerpinA1 improves energy and glucose. metabolism through regulation of preadipocyte proliferation and UCP1 expression.
   Nature Commun. 15(1):9585. 2024.