Departments
Integrated Medical and Pharmaceutical Sciences

Metabolic Medicine

Division
Integrated Medical and Pharmaceutical Sciences
Great Departments
Metabolic and Cardiovascular Medicine

Staff

Professor KUBOTA Naoto
nkubota0511(at mark)kumamoto-u.ac.jp
Associate Professor MATSUMURA Takeshi
takeshim(at mark)gpo.kumamoto-u.ac.jp
Lecturer KONDO Tatsuya (University Hospital Affiliation)
t-kondo(at mark)gpo.kumamoto-u.ac.jp
Assistant Professor SAKAGUCHI Masaji
msakaguchi(at mark)kumamoto-u.ac.jp
Assistant Professor FUKUDA Kazuki 
fukudakazuki(at mark)kumamoto-u.ac.jp

Research theme

In the Department of Metabolic Medicine, we are conducting clinical research aimed at advanced medical
care by advancing the molecular biological elucidation of pathological conditions in diabetes, metabolic
diseases, and endocrine diseases.

In the field of diabetes, we are focusing on the studies of the

(1) Elucidation of the pathogenesis of type 2 diabetes and development of new treatments
(2) Relationship between heat stress response pathway activation and insulin resistance, pancreatic α/β cell
function, and arteriosclerosis
(3) Regulation of insulin action transmitter expression and its significance in disease pathology
(4) Application of newly identified miRNAs to diabetes treatment

In the field of endocrinology, we are focusing on the studies of the

(1) Development of a highly sensitive diagnostic method for primary aldosteronism
(2) Role of inflammatory cytokines in primary aldosteronism
(3) Pathophysiology of glucose intolerance in acromegaly.

In the field of lipid metabolism, atherosclerosis and obesity, we are focusing on the studies of the

(1) Research on preventing the progression of arteriosclerosis by regulating macrophage proliferation
(2) Research on the clinical utility of non-invasive fingertip Advanced Glycation End Products (AGEs)
content measurement in type 2 diabetes
(3) Research on the significance of insulin action in the regulation of pancreatic acinar cells
(4) Elucidation of the onset mechanism of type 2 diabetes due to aging in Japanese