Microbiology

Interactions between pathogens and hosts (humans) play a crucial role in the development and prognosis of infectious diseases. Our laboratory has discovered that molecules known as supersulfides, which are composed of catenated sulfur atoms, are produced endogenously in the body and are critically involved in the regulation of diverse biological functions. Cysteine persulfide (Figure 1) is one such type of supersulfide. We have previously demonstrated that viral infections reduce the levels of host-derived supersulfides, and that supplementation of these depleted supersulfides can markedly ameliorate viral pathogenesis. We are currently advancing research aimed at developing novel therapeutic strategies for infectious diseases by regulating supersulfide dynamics.

In addition, we study the mechanisms of retroviral infection, focusing in particular on human immunodeficiency virus (HIV) and human T-cell leukemia virus (HTLV), as well as the regulation of endogenous retroviruses. Utilizing virological and molecular biological approaches, we aim to elucidate the interactions between viruses and host cells, from viral attachment to cellular receptors through to particle assembly and release. We are also working to translate these findings into innovative therapeutic strategies for viral infections.

Fig. 1. Structure of cysteine persulfide.