Department of Pharmacology and Molecular Therapeutics
Great Departments / Pharmacotherapeutics
|Assistant Professor||Hoichi Yorinaka
|Assistant Professor||Nobutaka Koibuchi|
Intracellular signal transduction molecules play a key role in a variety of cellular function, such as cell growth, apoptosis, and gene expression, and therefore seems to be the useful candidate for therapeutic target of cardiovascular diseases. To develop a new therapeutic agent for cardiovascular diseases, we investigate the molecular mechanism of cardiovascular diseases, focusing on protein kinases and transcription factors. Our another project is to elucidate the pharmacological effect of renin-angiotensin system inhibitors and other cardiovascular drugs on various cardiovascular diseases including hypertension, heart failure, atherosclerosis, and stroke, at the molecular level. Our most important goal is to develop translational research including gene therapy, in collaboration with departments of clinical medicine and industries.
Inhibition of balloon injury-induced vascular neointimal formation by gene transfer of dominant negative mutants of MAP kinase family.