|Division||Integrated Medical and Pharmaceutical Sciences|
|Great Department||Medicinal Chemistry|
|Assistant Professor||Shingo Itou|
|Assistant Professor||Mio Hirayama|
Structure of fattiviracins FV-8
And also, we are searching for new antitumor and antiviral drugs produced by microorganisms. Topoisomerases are known to be the target enzymes of antitumor drugs. Topostatin and isoaurostatin having novel structures are the antitumor drugs of new type which do not give DNA damage unlike the conventional antitumor drugs. Fattiviracins found as antiviral agents are novel compounds effective for herpes, human immunodeficiency and influenza virus. Fattiviracins will be in clinical use for the treatment of viral diseases. Now, we have tried to find more effective antitumor and antivirus drugs by carrying out syntheses of the structure analogues.