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department
department
Division / Advanced Biomedical Sciences
Department of Microbiology
Great Departments / Microbiology and Immunology
Website
Staff
Professor SAWA Tomohiro
Associate Professor MAEDA Yosuke
ymaeda(at mark)kumamoto-u.ac.jp
Assistant Professor TSUTSUKI Hiroyasu
Assistant Professor ONO Katsuhiko
Assistant Professor MONDE Kazuaki
Research theme

Nitric oxide (NO) and reactive oxygen species produced during infection and inflammation can cause chemical modifications (e.g., oxidation, nitration, nitrosylation) of biomolecules including proteins, lipids, nucleic acids, that modulate their physiological functions. We identified for the first time the endogenous guanine nitration to form 8-nitroguanine derivatives. Recently, 8-nitro-cGMP, a nitrated derivative of an intracellular signal molecule cyclic GMP (cGMP), was found to be formed in cells. More important, 8-nitro-cGMP thus formed is found to possess unique signal functions via induction of a novel post-translational modification of proteins, i.e., protein S-guanylation, which may be involved in host defense and pathological events, e.g., NO-related signaling, cell death, and carcinogenesis.

  1. (A) Chemical structure of 8-nitro-cGMP.
  2. (B, C) Immunostaining of 8-nitroguanine derivatives of the lung tissue from patients with IPF.
  3. (D) A novel post-translational modification of proteins (protein S-guanylation) induced by 8-nitro-cGMP.