We are working on following projects: 1) the analyses of pathological mechanism and therapeutic approaches for amyloidosis, 2) the genetic/pathological analysis of hereditary cerebral small vessel disease (SVD) such as CADASIL, 3) the assessment of the thrombolytic therapy for the hyper acute stage of the Stroke with MRI/CT, ultrasonography, DSA, and SPECT, 4) the analyses of pathophysiological mechanisms and development of the effective therapies for neuromuscular disorders such as ALS and sIBM, and 5) neuroimmunological studies.

Figure 1: Therapeutic targets for hereditary transthyretin amyloidosis

Figure 2: LMD-LC-MS/MS for analyzing amyloid deposits.

Figure 3: CADASIL. Typical distribution of white matter lesions (upper). GOM (lower left), and NOTCH3 R133C mutation (lower right).